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QuilliChew (methylphenidate hydrochloride chewable tablets) is available in three dosage strengths – 20 mg, 30 mg and 40 mg. The dosage strengths are expressed in terms of methylphenidate hydrochloride equivalents; however only 15% of methylphenidate is present as methylphenidate hydrochloride salt. The remaining 85% is present as methylphenidate ionically-bound to the sulfonate groups of sodium polystyrene sulfonate particles. QuilliChew contains approximately 30% immediate-release and 70% extended-release methylphenidate.
The QuilliChew chewable tablets are cherry flavored.
Methylphenidate HCl is a central nervous system (CNS) stimulant. The chemical name is methyl α-phenyl-2- piperidineacetate hydrochloride, and its structural formula is shown in Figure 1.
Figure 1: Methylphenidate HCl
QUILLICHEW (methylphenidate hydrochloride) – Structural Formula Illustration
Methylphenidate HCl is a white, odorless crystalline powder. Its solutions are acid to litmus. It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone.
QuilliChew also contains the following inactive ingredients: aspartame cherry flavor, citric acid, crospovidone, D&C red #30 (for 30 mg strength), D&C red #7 (for 40 mg strength), guar gum, magnesium stearate, mannitol, microcrystalline cellulose, polyvinyl acetate, polyvinyl alcohol, povidone, silicon dioxide, sodium polystyrene sulfonate, talc, triacetin, xanthan gum.
This medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Methylphenidate belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.
How to use Quillichew
Read the Medication Guide provided by your pharmacist before you start taking methylphenidate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
QuilliChew is the only , chewable central nervous system stimulant primarily used to treat attention deficit hyperactivity disorder (ADHD) in children ages 6-12, adolescents, and adults. It is especially useful for the one-third of children who can’t swallow pills. QuilliChew ay improve focus, and decrease impulsivity and hyperactive behavior, hallmark symptoms in some patients with the condition. It contains the same active ingredient as medications like Ritalin and Daytrana. According to the FDA, Quillichew is a federally controlled substance (CII) because it can be abused or lead to dependence. It has not been studied in children under the age of 6.
This guide should not replace a conversation with your doctor, who has a holistic view of your or your child’s medical history, other diagnoses, and other prescriptions. If you have questions, ask your doctor or pharmacist before you begin taking the medication.
Avoid drinking alcohol. Alcohol may cause extended-release methylphenidate to be released into the bloodstream too fast.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs methylphenidate, and may increase side effects.
Many drugs can affect methylphenidate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
As with all medications, follow your QuilliChew rescription instructions exactly. Tablets are available in 20mg, 30mg, and 40mg dosages. 20mg and 30mg tablets are scored and can be cut in half if necessary to achieve the right dose.
It is taken once daily in the morning with or without food. Chew each tablet well, and swallow with a full glass of water or another liquid. The time-release formulation is designed to maintain a steady level of medication in your body throughout the day.
The recommended starting dose of QuilliChew or patients 6 years and above is 20 mg once daily in the morning. The dose may be titrated weekly in increments of 10 mg to 20 mg. Daily dosages above 60 mg have not been studied and are not recommended.
The optimal dosage varies patient by patient. It is not determined by age, weight, or height, but rather by how a person metabolizes the medication, and by the condition treated. Your doctor may adjust your daily dosage until you or your child experiences the best response — that is, the lowest dosage at which you experience the greatest improvement in symptoms without side effects.
During treatment, your doctor may periodically ask you to stop taking your Quillichew so that he or she can monitor ADHD symptoms; check vital statistics including blood, heart, and blood pressure; or evaluate height and weight. If any problems are found, your doctor may recommend discontinuing treatment.
Some patients report developing a tolerance to QuilliChew ater long-term use. If you notice that your dosage is no longer controlling your symptoms, talk to your doctor to plan a course of action.
Before taking methylphenidate, tell your doctor or pharmacist if you are allergic to it; or to dexmethylphenidate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, stroke, personal or family history of heart problems (such as irregular heartbeat, heart attack, heart failure, heart valve problem), blood circulation problems (such as Raynaud’s disease), glaucoma, personal or family history of regular use/abuse of drugs/alcohol, personal or family history of mental/mood disorders (such as bipolar disorder, depression, psychosis, suicidal thoughts), personal or family history of uncontrolled muscle movements (motor tics, Tourette’s syndrome), overactive thyroid (hyperthyroidism), seizures.
This medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to limit/avoid aspartame (or phenylalanine) in your diet, ask your doctor or pharmacist about using this medication safely.
This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.
Before having surgery, tell your doctor or dentist about all the products you use (such as prescription drugs, nonprescription drugs, and herbal products).
If used for a long time, this drug may affect a child’s growth rate, weight, and final adult height. To reduce the risk, the doctor may recommend briefly stopping the medication from time to time. Check the child’s weight and height regularly, and consult your doctor or pharmacist for more details.
Older adults may be more sensitive to the side effects of this drug, especially trouble sleeping, weight loss, or chest pain.
During pregnancy, methylphenidate should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This medication passes into breast milk. Consult your doctor before breast-feeding.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
signs of heart problems–chest pain, trouble breathing, feeling like you might pass out;
signs of psychosis–hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
signs of circulation problems–numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
a seizure (convulsions);
muscle twitches (tics);
changes in your vision; or
penis erection that is painful or lasts 4 hours or longer (rare).
Methylphenidate can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common side effects may include:
mood changes, feeling nervous or irritable, sleep problems (insomnia);
fast heart rate, increased blood pressure;
loss of appetite, weight loss;
nausea, stomach pain; or headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects
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